Synergy of Nras mutation and Nup98-Hoxa10HD gene fusion efficiently preserves the stemness of single hematopoietic stem cells after feeder-free culture

Name: Synergy of Nras mutation and Nup98-Hoxa10HD gene fusion efficiently preserves the stemness of single hematopoietic stem cells after feeder-free culture
Creator: Institute of Blood Transfusion, Chinese Academy of Medical Sciences
Published: 2022-02-20T00:00:00+08:00

干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录

基因突变

造血干细胞

数据链接：

http://data.iscr.ac.cn/Article?id=3ca4e1dfda2f814b30ad4aa38af6c0bb 数据链接链接失效反馈

官方服务：

资源简介：

Hematopoietic stem cell (HSC) gives rise to all the hematopoietic cells. The stemness of HSC is strictly controlled by some transcription factors. Here we show that both of Nras mutation (NrasG12D) and Nup98-Hoxa10HD (NA) improve the transplantation competition ability of HSC. Pathways and differential expression genes analysis show that NrasG12D and NA proteins enhance the competitiveness of HSCs via distinct signaling mechanisms.

提供机构：

Institute of Blood Transfusion, Chinese Academy of Medical Sciences

创建时间：

2022-02-20