From altogether 220 million paired-end sequence reads from seven CRC cell lines we identified 3391 candidate fused transcripts, each with at least five-fold coverage across the fusion partners and at
BackgroundEchinoderm microtubule-associated protein-like 4 (EML4) is the canonical anaplastic lymphoma kinase (ALK) fusion partner in non-small cell lung cancer (NSCLC), and ALK-positive patients show
Somatic chromosomal deletions are prevalent in cancer, yet their effects are poorly understood. The most prominent homozygous deletions affect chromosome 9p21.3 and eliminate the CDKN2A/B tumor suppre
We used genome-wide microarray comparative genomic hybridization to carry out a higher resolution evaluation of the effect of MMR competence on genomic alterations occurring in 20 cell lines and to de
DNA copy-number profiling of 10 primary stPNETs Keywords: Genetic modification Comparison of tumor DNA (stPNET) versus control DNA (pool of lymphocyte DNA from 10 healthy donors). Whole-genome screeni
