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Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21. Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

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Method: Analysis of the transcriptomal changes of EV-GFP uptake by microglia after implantation of glioma cells into miR-21 null mouse brain. Result: miR-21 is transferred from glioma to microglia through EV, resulting in downregulation of miR-21 target mRNAs Overall design: mRNA expression of microglia isolated from control and tumor-bearing miR-21 null brains analyzed by RNAseq, using Illumina Nextseq.

创建时间:
2019-02-04
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