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Iron-Catalyzed Formation of 2‑Aminopyridines from Diynes and Cyanamides

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NIAID Data Ecosystem2026-03-09 收录
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Diynes and cyanamides undergo an iron-catalyzed [2 + 2 + 2] cycloaddition to form highly substituted 2-aminopyridines in an atom-efficient manner that is both high yielding and regioselective. This system was also used to cyclize two terminal alkynes and a cyanamide to afford a 2,4,6-trisubstituted pyridine product regioselectively.

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2016-02-20
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