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Mass Spectrometry-GUided Immunoassay DEvelopment (MS-GUIDE)

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NIAID Data Ecosystem2026-03-13 收录
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We applied targeted MS (parallel reaction monitoring, PRM) to pre-qualify candidates for clinical ELISA assay development. Literature harvested potential biomarker candidates, for which typically no antibodies for sensitive detection in complex samples exist, were evaluated in a medium-sized patient cohort using PRM. After biomarker validation, clinical grade ELISAs were developed and tested in a larger independent patient cohort.

创建时间:
2022-04-14
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