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Use of hiPSC-Derived Cardiomyocytes to Rule Out Proarrhythmic Effects of Drugs: The Case of Hydroxychloroquine in COVID-19

NIAID Data Ecosystem2026-03-14 收录

药物心脏安全性评估

hiPSC-CMs模型

数据链接：

https://zenodo.org/record/7546566 数据链接链接失效反馈

官方服务：

资源简介：

Raw and unfiltered datasets used for the publication.

应用场景：

创建时间：

2023-01-18

药物心脏安全性评估

心律失常预测

The International Council on Harmonization (ICH) S7B and E14 regulatory guidelines are sensitive but not specific for predicting which drugs are pro‐arrhythmic. In response, the Comprehensive In Vitro

NIAID Data Ecosystem70

ECG results (QTc) in ms by allocation arm and age-group in per protocol analysis.

心电图监测

药物心脏安全性评估

ECG results (QTc) in ms by allocation arm and age-group in per protocol analysis.

Figshare2024-10-21 更新50

Table_1_Long-Term Cardiac Safety and Survival Outcomes of Neoadjuvant Pegylated Liposomal Doxorubicin in Elderly Patients or Prone to Cardiotoxicity and Triple Negative Breast Cancer. Final Results of the Multicentre Phase II CAPRICE Study.docx

乳腺癌新辅助化疗

药物心脏安全性评估

BackgroundThe CAPRICE trial was designed to specifically evaluate neoadjuvant pegylated liposomal doxorubicin (PLD) in elderly patients or in those with other cardiovascular risk factors in whom conve

NIAID Data Ecosystem20

Astemizole: effects of oral administration on haemodynamic and electrocardiographic parameters in the chronically-instrumented conscious primate using telemetry

药物心脏安全性评估

临床前药效学

N=4 male conscious telemetered Cynomolgus monkeys, dosed with astemizole at 3, 10 and 30 mg/kg ? successively per os. No PK phase. Haemodynamic parameters (SAP, DAP, MAP, HR). Lead II ECG (RR, PR, QRS

NIAID Data Ecosystem60

Electrocardiographic QTc measurements by allocated treatment.

心电图分析

药物心脏安全性评估

IQR, interquartile range.Electrocardiographic QTc measurements by allocated treatment.

Figshare2015-12-02 更新50