Assessment of DNA methylation patterns in osteoarthritic baboon bone and cartilage using the 450K array

The aim of this study was to identify DNA methylation patterns in femur trabecular bone and cartilage of age-matched female baboons, five with and five without knee osteoarthritis. The Illumina Infinium Human Methylation450 BeadChip was used to assess these genome-wide methylation patterns. Bisulphite converted DNA from the 10 baboons (n=10 bone samples, n=10 cartilage samples) were hybridized to the Illumina Infinium Human Methylation450 BeadChip. Please note that the sample data table contain the 'matrix_norm_alignmentfilter_beta' data. However, the study's conclusions are based on both norm_*_beta.csv data (linked as Series supplementary files). It compares and contrasts both filtering criteria.