Synthesis of (−)-Homogalanthamine from Naltrexone
收藏NIAID Data Ecosystem2026-03-07 收录
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Acetylcholinesterase inhibitor (−)-homogalanthamine 3 was synthesized from μ opioid antagonist naltrexone (2) in 16% total yield. The synthesis features Grob fragmentation as a key reaction, which was especially accelerated in the presence of 15-crown-5.
创建时间：
2016-02-23
