ToxRefDB v2.1

Toxicity Reference Database (ToxRefDB) contains in vivo study data from over 5900 guideline or guideline-like studies for over 1100 chemicals. By employing a controlled vocabulary for enhanced data quality, ToxRefDB (v2.1, released August 2022) serves as a resource for study design, quantitative dose response, and endpoint and effect controlled vocabulary linked to the required, recommended, or triggered measurements indicated by corresponding guideline specifications. The database can aid in the validation of in vitro high-throughput screening of chemicals and support retrospective and predictive toxicology applications.毒性参考数据库（Toxicity Reference Database，ToxRefDB）收录了1100余种化学品的5900余项官方指南或类指南研究的体内实验数据。该数据库通过采用受控词汇表以提升数据质量，2022年8月发布的2.1版ToxRefDB可作为研究设计、定量剂量反应分析，以及与对应指南规范中规定、推荐或触发型测量指标相关联的效应终点与效应受控词汇表的参考资源。该数据库可辅助化学品体外高通量筛选的验证工作，并为回顾性毒理学与预测性毒理学应用提供支撑。

搜集汇总

背景与挑战

背景概述

ToxRefDB v2.1是一个毒性参考数据库，包含超过5900项体内研究数据，涉及1100多种化学物质，用于支持化学物质的高通量筛选验证和毒理学研究。