INTRODUCTION: Frontotemporal dementia (FTD) is characterized by progressive atrophy of frontal and/or temporal cortices and considerable clinical, pathological, and genetic heterogeneity. METHODS: Fro

NIAID Data Ecosystem20

Additional file 15 of Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain

神经退行性疾病蛋白质

阿尔茨海默病生物标志物

Additional file 15: Table S4. All proteins normalized to soluble fraction and then ranked by spectral counts (using method from Table 2).

Figshare2020-06-19 更新10

Radiation-Induced Alteration of the Brain Proteome: Understanding the Role of the Sirtuin 2 Deacetylase in a Murine Model

辐射生物学

神经退行性疾病蛋白质

Whole brain radiotherapy (WBRT) produces unwanted sequelae, albeit via unknown mechanisms. A deacetylase expressed in the central nervous system, Sirtuin 2 (SIRT2), has been linked to neurodegeneratio

NIAID Data Ecosystem30

Increased levels of mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol

神经退行性疾病蛋白质

线粒体蛋白输入调控

The formation of protein aggregates is a hallmark of neurodegenerative diseases. Observations on patient samples and model systems demonstrated links between aggregate formation and declining mitochon

NIAID Data Ecosystem20

Proteomic analysis of substantia nigra

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