RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160

Based on studies with recombinant human proteins and Xenopus egg extracts, RAN:GTP binds to transportin (TNPO1) or importin beta (KPNB1) associated with the Nup107-160 complex (Lau et al. 2009), resulting in release of the latter.基于重组人蛋白和非洲爪蟾卵提取物的研究，RAN:GTP与Nup107-160复合物（Lau 等人，2009年）相关的运输蛋白（TNPO1）或导入蛋白β（KPNB1）结合，导致后者的释放。