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Cross-linking MS of S. cerevisiae ORC bound to DNA and Cdc6

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NIAID Data Ecosystem2026-03-13 收录
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During DNA replication initiation, the Origin Recognition Complex (ORC) and Cdc6 co-associate on DNA to load replicative helicases onto origins of replication. We apply DSSO crosslinking mass spectrometry of reconstituted ORC-DNA-Cdc6 to identify interactions between different subunits and domains in the complex.

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2022-02-28
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