Ikaros mediates gene silencing in T cells through Polycomb Repressive Complex 2

NIAID Data Ecosystem2026-03-09 收录

T细胞表观遗传调控

基因沉默机制

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA260351 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

创建时间：

2014-09-05

Regulation of T cell cytokine expression by Tet2-mediated DNA demethylation [MeDIP-Seq]

T细胞表观遗传调控

细胞因子作用机制

T cell function is regulated by epigenetic mechanisms. 5-methylcytosine (5mC) conversion to 5-hydroxymethylcytosine (5hmC) by ten-eleven translocation (Tet) proteins was identified to mediate DNA deme

NIAID Data Ecosystem50

Tet2 inactivation enhances the anti-tumor activity of tumor-infiltrating lymphocytes

肿瘤免疫治疗

T细胞表观遗传调控

Inactivation of tumor infiltrating lymphocytes (TILs) is one of the limiting factors of anti-tumor immunity during tumor onset and progression. Epigenetic abnormalities are regarded as a major culprit

NIAID Data Ecosystem30

Three-dimensional chromatin reorganization during CD8+ T cell activation is mediated by TRIM28 [ChIP-Seq]

染色质空间结构

T细胞表观遗传调控

T cell activation is accompanied by extensive changes in epigenome. However, whether and how high-ordered chromatin organization is involved in CD8+ T cell activation is unclear. Here, we showed exten

NIAID Data Ecosystem30

Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation [ChIP,CutRun]

T细胞表观遗传调控

Foxp3基因表达

Regulatory T (Treg) cells play crucial roles in suppressing deleterious immune response. Here, we investigate how mechanistically Treg cells are induced and stabilized via transcriptional regulation o

NIAID Data Ecosystem40

Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation [ATAC-Seq]

T细胞表观遗传调控

Foxp3

NIAID Data Ecosystem30