Additional file 2: Figures S4-S6. of B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis

Dkk-1 is not expressed in epidermis (black arrow), appendices (green arrow) and spindle-like cells (red arrows) prior to (A and B) and following RTX treatment (D and E). These patients did not respond to RTX treatment. Streptavidin biotin peroxidase (A and D × 20, B and E × 400) (ZIP 5591 kb)