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LSD1 inhibitors trigger myeloid differentiation by targeting the LSD1-GSE1 interaction on chromatin. LSD1 inhibitors trigger myeloid differentiation by targeting the LSD1-GSE1 interaction on chromatin

NIAID Data Ecosystem2026-03-12 收录

LSD1抑制剂

髓系分化机制

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA691206 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2021-01-11

冠状病毒免疫反应

LSD1抑制剂

Innate responses to coronavirus are highly cell-specific and remain to date incompletely understood. Tissue-resident macrophages, which are infected by SARS-CoV2 in patients but inconsistently in vitr

NIAID Data Ecosystem60

Plasma and B cells from mice treated with GSK-LSD1. Mus musculus

LSD1抑制剂

B细胞与浆细胞功能

We treated mice daily with the GSK-LSD1 or vehicle for 21 days. B and plasma cells were isolated by FACS and RNA-seq performed. Pathway analysis showed that MYC targets, Unfolded protein response, TNF

NIAID Data Ecosystem30

RB1 loss promotes a noncanonical activator function of LSD1 and sensitizes castration-resistant prostate cancer to LSD1 inhibition [RNA-seq]. RB1 loss promotes a noncanonical activator function of LSD1 and sensitizes castration-resistant prostate cancer to LSD1 inhibition [RNA-seq]

去势抵抗性前列腺癌(CRPC)

LSD1抑制剂

Genomic loss of RB1 is a common alteration in castration-resistant prostate cancer (CRPC) and is associated with poor patient outcomes. RB1-loss is also a driver event that promotes the neuroendocrine

NIAID Data Ecosystem30

Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

环肽

LSD1抑制剂

Lysine-specific demethylase 1 (LSD1) is an epigenetic enzyme which regulates the methylation of Lys4 of histone 3 (H3) and is overexpressed in certain cancers. We used structures of H3 substrate analo

NIAID Data Ecosystem50

Inhibitors of LSD1 target demethylase-independent activity to induce differentiation in acute myeloid leukemia [anti-H3K9 ac, anti-H3K27, RCOR1, SPI1, and MLL4 ChIP-Seq]. Inhibitors of LSD1 target demethylase-independent activity to induce differentiation in acute myeloid leukemia [anti-H3K9 ac, anti-H3K27, RCOR1, SPI1, and MLL4 ChIP-Seq]

急性髓系白血病表观遗传

LSD1抑制剂

To determine whether changes in histone modifications directly correlate with changes in transcription, THP1 AML cells were treated with a potent and selective LSD1 inhibitor (OG86, 250nM) and then su

NIAID Data Ecosystem30

LSD1 inhibitors trigger myeloid differentiation by targeting the LSD1-GSE1 interaction on chromatin. LSD1 inhibitors trigger myeloid differentiation by targeting the LSD1-GSE1 interaction on chromatin

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