Surface ECGs were obtained in lightly anesthesized mice. Data represent the means ± SE. Statistical significance was determined by pair-wise comparisons with a Tuckey-Kramer test, or χ2 analysis. WT,
Experimental details were as in Figure 1. A) Similar blood glucose by genotype at the start (0 wk) of the 20 wk study and sustained blood glucose lowering by AZD1656 (3mg/kg) after 19 wk compared to 2
The targeting of proinflammatory pathways has a prophylactic and therapeutic potential on atherosclerotic cardiovascular diseases (CVD). An alternative/complementary strategy is the promotion of endog