Dissecting Super-enhancer driven Transcriptional Dependencies Reveals Novel Oncogenes and Therapeutic Strategies of Group 3 Subtype Medulloblastoma

NIAID Data Ecosystem2026-03-14 收录

髓母细胞瘤Group3亚型

增强子转录调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE185025 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2022-10-27

An eRNA Transcription Checkpoint For Diverse Signal-dependent Enhancer Activation Programs [ATAC-Seq]. An eRNA Transcription Checkpoint For Diverse Signal-dependent Enhancer Activation Programs [ATAC-Seq]

增强子转录调控

表观遗传

The evidence that several signal and ligand-dependent pathways function by activating regulatory enhancer programs suggests that a “checkpoint” strategy may underline activation of some or even many d

NIAID Data Ecosystem30

Dissecting Super-enhancer driven Transcriptional Dependencies Reveals Novel Oncogenes and Therapeutic Strategies of Group 3 Subtype Medulloblastoma [RNA-seq]. Dissecting Super-enhancer driven Transcriptional Dependencies Reveals Novel Oncogenes and Therapeutic Strategies of Group 3 Subtype Medulloblastoma [RNA-seq]

髓母细胞瘤Group3亚型

增强子转录调控

Medulloblastoma (MB) is the most common malignant pediatric brain tumor and group 3 subtype (G3-MB) exhibits the worst prognosis. Dissecting super-enhancer (SE) driven transcriptional dependencies of

NIAID Data Ecosystem30

Global hyperactivation of enhancers stabilizes human and mouse naÃ¯ve pluripotency [RNA-seq]

初始多能性稳定化

增强子转录调控

The transition of pluripotent stem cells (PSCs) from primed to naÃ¯ve states constitutes a prototypical example of cellular plasticity. The naÃ¯ve state can be stabilized by defined chemical cocktail

NIAID Data Ecosystem20

OTX2 activity at distal regulatory elements shapes the chromatin landscape of Group 3 medulloblastoma. OTX2 activity at distal regulatory elements shapes the chromatin landscape of Group 3 medulloblastoma

髓母细胞瘤Group3亚型

OTX2染色质调控

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem30

RNA-seq analysis of pro-B cells from RAG, double RAG/Emu, double RAG/3'RR and double RAG/KOKI deficient mice.

B细胞发育

增强子转录调控

By their impact on nuclear organisation, enhancers are master regulators of cell fate. We thus developed double Emu-RAG-deficient, 3’RR-RAG-deficient mice and KOKI-RAG-deficient mice to investigate a

NIAID Data Ecosystem20

Dissecting Super-enhancer driven Transcriptional Dependencies Reveals Novel Oncogenes and Therapeutic Strategies of Group 3 Subtype Medulloblastoma

资源简介：

相关数据集