Schematic representation of human chromosome 21 long-arm comprised of mouse chromosomal segments from chromosomes 16, 17, and 10. The portion of chromosome 16 that is found in trisomy in the Ts65Dn mo
We have created the Ts66Yah a new model for Down syndrome or T21, derived from the Ts65Dn. Ts66Yah does not contain a set of genes present in 3 copies that are not linked to T21. On this model (Ts66),
Down syndrome (DS), a genetic condition leading to intellectual disability, is characterized by triplication of human chromosome 21. Neuropathological hallmarks of DS include abnormal central nervous
