In this study, we show that fully viral gene-deleted adenoviral vector delivery of donors prone to HMEJ and HR, together with matched CRISPR-Cas9 complexes, achieves targeted chromosomal integration o
Mutant Psen1-P436S mice were generated by Base Editor and Target-AID by microinjection into mouse zygotes. This database includes off-target mutations in the mutant Psen1-P436S mice. Target sites were
Zinc Finger Nucleases (ZFNs) facilitate precise editing of DNA enabling targeted genomic modifications in vivo. ZFNs have been employed to obtain genetically modified plants and animals, and cell-base