Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity [BAT]

Analysis of brown adipose tissue from Yin Yang 1 (YY1) brown fat specific knockout mice fed a high fat diet for 3 months. YY1 deficiency in brown adipose tissue leads to strong thermogenic deficiency. The goal was to identify the genes controlled by YY1 responsible of brown fat defective function. Control mice YY1flox/flox versus YY1flox/flox; Ucp1Cre were fed a high fat diet for 3 months本研究对经高脂饮食喂养3个月的棕色脂肪特异性敲除阴阳因子1（Yin Yang 1, YY1）小鼠的棕色脂肪组织开展分析。该模型中棕色脂肪组织的YY1缺失会引发严重的产热功能缺陷，本研究的目标为筛选受YY1调控、与棕色脂肪功能缺陷相关的基因。本研究设置两组受试小鼠：对照组为YY1flox/flox小鼠，实验组为YY1flox/flox; Ucp1Cre小鼠，两组均接受高脂饮食喂养3个月。