Comprehensive fitness maps of Hsp90 show widespread environmental dependence

NIAID Data Ecosystem2026-03-11 收录

蛋白质深度突变扫描

环境依赖性适应度图谱

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP234932 数据链接链接失效反馈

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资源简介：

Deep mutational scanning of all amino acid variants of Hsp90 in budding yeast in six different environmental conditions.

创建时间：

2019-12-09

Deep mutational scanning of the Neisseria meningitis major pilin reveals the importance of pilus tip-mediated adhesion

细菌毒力因子功能分析

蛋白质深度突变扫描

Type IV pili (TFP) are multifunctional micrometer-long filaments expressed at the surface of many prokaryotes. In Neisseria meningitidis, TFP are crucial for virulence. Indeed, these homopolymers of t

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A focused deep mutational scan on the Env transmembrane and proximal cytosolic regions reveals an absence of sequence features for MA association. A focused deep mutational scan on the Env transmembrane and proximal cytosolic regions reveals an absence of sequence features for MA association

病毒组装机制

蛋白质深度突变扫描

The HIV-1 surface glycoprotein Env binds target receptors to mediate fusion of the viral and host cell membranes during infection. Env is incorporated with very low density into virions, and in some c

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Plasmodium falciparum Raw sequence reads

寄生虫抗原研究

蛋白质深度突变扫描

Deep mutational scanning of the circumsporozoite protein (CSP) N-terminal domain using yeast display. Antibody 5D5 was used for selection.

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Deep mutational scanning of essential bacterial proteins can guide antibiotic development

抗生素发现

蛋白质深度突变扫描

Deep mutational scanning is a powerful approach to investigate a wide variety of research questions including protein function and stability. We performed deep mutational scanning on three essential E

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Critical residues within the TAPBPR scoop loop for HLA-A2 binding and peptide loading are determined by deep mutational scanning

MHC-I肽装载机制

蛋白质深度突变扫描

The loading of high affinity peptides onto nascent class I MHC (MHC-I) molecules is facilitated by chaperones, including the class I-specific chaperone TAP-binding protein-related (TAPBPR). TAPBPR fea

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Comprehensive fitness maps of Hsp90 show widespread environmental dependence

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