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Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and raltegravir at 2.65 resolution

NIAID Data Ecosystem2026-05-01 收录

病毒整合酶-药物复合物结构

艾滋病药物设计

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Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and raltegravir at 2.65 resolution

应用场景：

创建时间：

2023-09-06

艾滋病药物设计

先导化合物

Integrase mutations can reduce the effectiveness of the first-generation FDA-approved integrase strand transfer inhibitors (INSTIs), raltegravir (RAL) and elvitegravir (EVG). The second-generation age

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Crystal structure of the wild type HIV-1 protease with the inhibitor, Amprenavir

HIV-1蛋白酶抑制剂

艾滋病药物设计

Crystal structure of the wild type HIV-1 protease with the inhibitor, Amprenavir Descriptor: ACETATE ION, Protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC AC

Protein Data Bank Japan2023-08-30 更新20

Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV‑1 Protease PR20

艾滋病药物设计

抑制剂优化

An extremely drug resistant mutant of HIV-1 protease (PR) bearing 20 mutations (PR20) has been studied with two potent antiviral investigational inhibitors. GRL-5010A and GRL-4410A were designed to in

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Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design

艾滋病药物设计

整合酶抑制剂

Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design Descriptor: 5-[[[2-[[(1S)-1-(4-METHOXYPHENYL)BUTYL]CARBAMOYL]PHENYL

Protein Data Bank Japan2023-12-20 更新30

Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors

蛋白质-配体共结晶

艾滋病药物设计

Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors Descriptor: O-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl] (4-chlorophenyl)thiocarbamate,

Protein Data Bank Japan2024-05-08 更新20

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and raltegravir at 2.65 resolution

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