Homo sapiens Exome

NIAID Data Ecosystem2026-05-01 收录

皮肤鳞状细胞癌基因突变分析

肿瘤治疗靶点

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https://www.ncbi.nlm.nih.gov/sra/SRP436373 数据链接链接失效反馈

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This study aimed to investigate the genetic mutation profile of the deeper portion of cutaneous squamous cell carcinoma cSCC compared to the superficial portion, identifying potential therapeutic targets for high-risk cSCC patients.

创建时间：

2023-06-01

Source Date LabZhang

癌症分子机制

肿瘤治疗靶点

BackgroundFork-head box protein M1 (FOXM1) plays critical roles in development and progression of multiple cancers, including hepatocellular carcinoma (HCC). However, the exact regulatory hierarchy of

DataCite Commons2025-02-09 更新60

Knocking-down of CREPT prohibits the progression of oral squamous cell carcinoma and suppresses cyclin D1 and c-Myc expression

鳞状细胞癌分子机制

肿瘤治疗靶点

Background As a regulator essential for many cell cycle-related proteins, the robust expression of Cell cycle-Related and Expression-elevated Protein in Tumor (CREPT) implicates a poor diagnosis of en

NIAID Data Ecosystem30

Next generation sequencing of A375 melanoma cell line revealed a complex regulatory network when IGFBP5 overexpressed. Homo sapiens

黑色素瘤分子机制

肿瘤治疗靶点

IGFBP5, a critical regulators of insulin-like growth factors, has been reported to be involved in many kinds of carcinogenesis and cancer metastases. The role of IGFBP5 in human malignant melanoma (MM

NIAID Data Ecosystem20

LPCAT1-mediated membrane phospholipid remodeling promotes ferroptosis evasion and tumor growth Raw sequence reads

铁死亡机制

肿瘤治疗靶点

The mechanisms underlying how cells dynamically remodel membrane phospholipids to prevent phospholipid peroxidation-induced membrane damage and evade ferroptosis, which maintains the physiological fun

NIAID Data Ecosystem40

Understanding the Mechanism of Insulin and Insulin-Like Growth Factor (IGF) Receptor Activation by IGF-II

IGF-II

肿瘤治疗靶点

BackgroundInsulin-like growth factor-II (IGF-II) promotes cell proliferation and survival and plays an important role in normal fetal development and placental function. IGF-II binds both the insulin-

Figshare2016-01-18 更新20

Homo sapiens Exome

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