CBFb-SMMHC inhibition triggers apoptosis by disrupting MYC chromatin dynamics in acute myeloid leukemia
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2021-07-25
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RNAseq raw data
Repurposing amiodarone as a targeted SIRT3 activator that induces autophagic/mitophagic cell death in acute myelocytic leukemia (RNAseq), this is the RNAseq raw data of this article, and there are thr
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MicroRNA-155 is upregulated in Hoxa9/Meis1 leukemia inducing cells but is dispensable for in vivo transformation and leukemia development. Mus musculus
OBJECTIVE: The microRNA miR-155 is upregulated in Hoxa9 and Meis1 leukemia inducing cells (LIC) , and miR-155 accelerates the onset of acute myeloid leukemia (AML) together with Hoxa9 but through larg
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Single base substitution and insertion/deletion mutational signatures in adult core binding factor acute myeloid leukemia
Paired diagnostic and remission samples from 20 adults with core binding factor acute myeloid leukemia (AML), comprising ten with t(8;21)(q22;q22) [RUNX1::RUNX1T1] and ten with inv(16)(p13q22)/t(16;16
data.europa2022-02-18 更新10
Determining the DNA-binding targets of NFATc2 in the AML cell line THP-1. Determining the DNA-binding targets of NFATc2 in the AML cell line THP-1
Based on previous work on the KDM histone demethylase family in AML, the transcription factor NFATC2 was identified as a regulatory target of KDM4A in MLL-AF9-rearrangement THP-1 cells. Our existing w
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CITE-seq (cellular indexing of transcriptomes and epitopes by sequencing) of WT and RAS mutant specimens from acute myeloid leukemia (AML) patients.. CITE-seq (cellular indexing of transcriptomes and epitopes by sequencing) of WT and RAS mutant specimens from acute myeloid leukemia (AML) patients.
To understand the role of RAS mutations in AML, we performed CITE-seq on diagnosis specimens from WT and RAS mutant AML patients. Overall design: Cells were harvested from AML patients at diagnosis an
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