Association between benzodiazepine prescribing in the first trimester of pregnancy and the risk of major congenital anomalies in offspring^a.

aChildren born to women with depression or anxiety but without anxiolytic, hypnotic or antidepressant drugs in the first trimester as the comparison group & gaps in the table indicated insufficient data available for the specific comparisons. bDoes not include children born to women with co-prescriptions of antidepressants in the first trimester of pregnancy. AOR = odds ratio adjusted for maternal age at childbirth and calendar year at birth at a categorical variables, body mass index and maternal smoking and socioeconomic status. MCAs = major congenital anomalies; CI = confidence interval.