The goal of this study was to understand how the GNAQ oncogene can either promote or inhibit the formation of melanoma. In the eye, activation of GNAQ through the Q209L mutation drives uveal melanoma.
Melanoma is a complex and genetically heterogeneous malignant tumor with high rates of mortality. Although current therapies provide a short-term clinical benefit, they are unable to cure the majority
With high genetic heterogeneity in melanoma, understanding epigenetic and transcriptional differences between melanocytes and melanoma cells will enable further understanding of the genes, pathways, a
