In this work, we show a role for Chd8 in the regulation of Xist RNA, the master regulator of X chromosome inactivation (XCI) Overall design: ES cells and differentiang ES cells (3 day differentiated c

NIAID Data Ecosystem50

Xist RNA antagonizes the chromatin remodeler, BRG1, from the inactive X chromosome

X染色体失活

染色质重塑调控

The noncoding Xist RNA recruits silencing factors to the inactive X (Xi) and facilitates re-organization of Xi structure. Here, we examine the epigenomic landscape of the Xi and assess how Xist alters

NIAID Data Ecosystem30

Additional file 4 of Identification of the RSX interactome in a marsupial shows functional coherence with the Xist interactome during X inactivation

蛋白质相互作用组学

X染色体失活

Additional file 4: Tab 1. Numbers of proteins and edges in STRING networks and each cluster of combined interactomes. Tab 2. Proteins in each cluster of combined interactomes. Tab 3. Proteins of combi

DataCite Commons2024-08-18 更新60

Data folder for X-Ra (https://github.com/isglobal-brge/Supplementary-Material/tree/master/Caceres_2024)

X染色体失活

癌细胞研究

X-chromosome inactivation (XCI) is a fundamental mechanism to compensate for gene dosage differences between sexes. Surveying methylation levels over inactivated regions, we establish quantitative lev

DataCite Commons2024-05-23 更新40

The role of XIST in X-inactivation maintenance in B cells. The role of XIST in X-inactivation maintenance in B cells

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