Depalmitoylation of eNOS

Increases in intracellular calcium and calmodulin stimulate depalmitoylation of eNOS by acyl protein thioesterase 1, which displaces eNOS from the membrane. This might be a mechanism to downregulate NO production following intense stimuli.细胞内钙离子和钙调蛋白的增加，通过酰基蛋白硫酯酶1介导，刺激内皮型一氧化氮合酶（eNOS）的脱棕榈酰化，从而将eNOS从细胞膜上移除。这可能是针对强烈刺激后下调一氧化氮（NO）产生的一种机制。