CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning

NIAID Data Ecosystem2026-03-12 收录

V(D)J重组

CTCF/cohesin调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE142781 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2020-10-08

RAG Represents a Widespread Threat to the Lymphocyte Genome - (ChIP-seq)

淋巴细胞

V(D)J重组

The RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination but is a potent threat to genome stability. The sources of RAG1 mistargeting and the mechanisms that have

NIAID Data Ecosystem30

Targeted Transposition by the V(D)J Recombinase

V(D)J重组

淋巴瘤染色体易位

Cleavage by the V(D)J recombinase at a pair of recombination signal sequences creates two coding ends and two signal ends. The RAG proteins can integrate these signal ends, without sequence specificit

PubMed Central20

ERG controls B-cell development by promoting Igh V-to-DJ recombination [ATAC-seq]

B细胞发育

V(D)J重组

B-cell development is dependent on the coordinated expression and cooperation of several transcription factors. Here, we show that the transcription factor ETS Related Gene (ERG) is crucial for normal

NIAID Data Ecosystem10

NUDCD3 deficiency disrupts V(D)J recombination to cause SCID/Omenn syndrome

先天性免疫缺陷疾病

V(D)J重组

Inborn errors of T cell development present a pediatric emergency in which timely curative therapy is informed by molecular diagnosis. In 9 affected patients across 3 consanguineous kindreds, we detec

NIAID Data Ecosystem20

Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination (LAM-HTGTS). Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination (LAM-HTGTS)

V(D)J重组

环挤压与基因座收缩

Immunoglobulin heavy chain locus (Igh) VH, D, and JH gene segments are developmentally assembled into V(D)J exons. RAG endonuclease initiates V(D)J recombination by binding a JH-recombination signal s

NIAID Data Ecosystem20

CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning

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