Control of the steady state ratio of cortisone to cortisol by 11β-HSD1 and H6PDH
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The ratio of cortisone to cortisol was measured after incubating HEK-293 cells expressing 11β-HSD1 or coexpressing 11β-HSD1 and H6PDH for 16 h in the presence of 200 nM of radiolabeled substrate. The effect of inhibitors was determined by coincubating cells with 20 µM of the corresponding compound. Data are given as percentage of total glucocorticoid and represent mean±SD, n = 4.
创建时间：
2015-12-02
