The goal of this study was to determine the mechanism by which a glutamate to lysine mutation of histone H2B at amino acid 76 (H2B-E76K), found particularly in bladder and head and neck cancer, may pr
We assessed methylation landscape near the human TERT promoter in various normal samples and tumor samples, to assess the unique hypermethylation phenotype that exist in human cancers Overall design:
Additional file 2: Table S1. WGBS data sets used in the current study. Table S2. F1-socres for three different callers in each tumor sample from the Blueprint consortium. Table S3. F1-socres for three
As a master regulator of chromatin structure and function, the EZH2 lysine methyltransferase orchestrates transcriptional silencing of developmental gene networks. Overexpression of EZH2 is commonly o
