Somatic mutations acquired in healthy tissues as we age are major determinants of cancer risk. Whether variants confer a fitness advantage or rise to detectable frequencies by change remains largely u
According to the Red Queen hypothesis, clonal diversity in asexual populations could be maintained by negative frequency-dependant selection by co-evolving parasites. If common clones are selected aga
The CH web page at http://www.genetictargets.com/CH/index.html includes data, codes, and instructions, supporting the reproducibility of the paper entitled 'The impact of age and number of mutations o
Most triple negative breast cancers (TNBCs) are aggressively metastatic with a high degree of intratumoral heterogeneity. We employed patient-derived xenograft models established from the breast tumor
