Osteoporosis and bone fragility fracture are multifactorial pathologies whose genetic component is still poorly characterized. The present experiment aims to identify genes differentially expressed in
Using ChIP-Seq, we show that Nfil3 is a transcriptional target of the PTH-NACA axis in osteoblasts. We also show that Nfil3 transcription is, by part, regulated by NACA and CREB. Finally, we show that
Osteoporosis is a metabolic bone disease characterized by a decrease in bone mass and degradation of the bone microstructure, which increases bone fragility and risk of fracture. However, the molecula
hMSC-C = control hMSC; hMSC-OP = osteoporotic hMSC; hMSC-old = hMSC of non-osteoporotic, elderly donors; hMSC-senescent = long term-cultivated hMSC in the state of replicative senescence; standard dev
