Ectopic Tcf1 expression reprograms exhausted CD8+ T cells to acquire stem cell-like features [ATAC-seq]

Name: Ectopic Tcf1 expression reprograms exhausted CD8+ T cells to acquire stem cell-like features [ATAC-seq]
Creator: Hackensack University Medial Center
Published: 2022-02-20T00:00:00+08:00

干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录

免疫学

细胞生物学

数据链接：

http://data.iscr.ac.cn/Article?id=c794ad8dac0a27fd0f4a27fa63aad71d 数据链接链接失效反馈

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资源简介：

The goal of this study is to determine the capacity of Tcf1 to reprogram exhausted CD8+ T cells for function restoration. Tex cells elicited by chronic infection contain a CXCR5+Tim3â subset that has stem cell-like self-renewing capacity and expresses an elevated level of Tcf1 (termed Tex-stem), and Tex-stem cells depend on Tcf1 for generation and persistence. We show that ectopic Tcf1 expression profoundly affected the chromatin accessibility of Tex cells.

提供机构：

Hackensack University Medial Center

创建时间：

2022-02-20