Revealing changes in gene expression in THP-1 cells induced by 1a THP-1 cells were grown in presence or absence of 1 µM 1a for 16 hours. RNA Profiling was obtained in triplicate using Illumina NextSeq
The FLT3-ITD mutation occurs in about 30% of acute myeloid leukemia (AML) and is associated with poor prognosis. However, FLT3 inhibitors are only partially effective and prone to acquired resistance.
To determine the gene expression levels in the fatty acid desaturase deleted mutant, vegetative hyphae of the wild type PH-1 and mutant were harvested from 18 hours YEPD cultures.
Posttranscriptional regulation of mRNA is a crucial component of gene expression. The disruption of this process can have detrimental effects on normal development and give rise to various diseases.
