Chaetocin Mediated Changes in Gene Expression Profile of GBM Cells

Chaetocin treatment significantly modulated expression profile of GBM cells such that 373 genes were up and 478 genes were down regulated significantly (FDR<0.05). Genes involved in DNA damage response, reactive oxygen species pathway and cell cycle regulation as well as epithelial to mesenchymal transition are significantly modified by Chaetocin, which render GBM cells much more prone to apoptosis. Examination of Chaetocin's effect on gene expression profile of U87MG cells. 2 sets of samples were prepared for Chaetocin treated (50 nM, 24h) and untreated (control) conditions.