Identifying Causes of Fracture Beyond Bone Mineral Density: Evidence from Human Genetics

Full Summary Statistics and Supplementary Tables ---------- Genomic structural equation models were built to investigate genetic effects on fracture that were mediated vs. not mediated by bone mineral density (BMD). ---------- Summary Statistics Frax-eBMD-related.gwas.txt.gz: genetic effects mediated by estimated BMD Frax-non-eBMD.gwas.txt.gz: genetic effects not mediated by estimated BMD Frax-FNBMD-related.gwas.txt.gz: genetic effects mediated by femoral neck BMD Frax-non-FNBMD.gwas.txt.gz: genetic effects not mediated by femoral neck BMD Frax-LSBMD-related.gwas.txt.gz: genetic effects mediated by lumbar spine BMD Frax-non-LSBMD.gwas.txt.gz: genetic effects not mediated by lumbar spine BMD ---------- Supplementary Tables Table S3. List of COJO-independent SNPs with BMD-related effects on fracture risk. Table S4. Statistical fine-mapping of loci conferring non-BMD effects. Table S5. GWAS signals identified by PhenoScanner for each COJO-independent SNP. Table S7. Parameter optimization for polygenic risk scores.