Age-dependent transcriptome characterization of the rat supraoptic nucleus (RNA-Seq). Age-dependent transcriptome characterization of the rat supraoptic nucleus (RNA-Seq)

Our prior studies indicat age-dependent contralateral axonal sprouting following unilateral lesion of magnocellular neurons in the supraoptic nucleus. To understand the changes in the transcriptome that underlies this phenomenon, we performed RNA-seq and functional analysis of the rat supraoptic nucleus to determine changes in gene expression with age. Overall design: Comparative gene expression of the supraoptic nucleus was performed on two age groups, 35 days and 125 days old. Each group consisted of 4 biological replicates. For each biological replicate, the supraoptic nuclei of 4 rats were pooled.