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Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging

NIAID Data Ecosystem2026-03-11 收录

蛋白质与染色质修饰与DNA修复

衰老生物学

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Original data for manuscript "Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging"

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创建时间：

2020-07-09

衰老生物学

分子生物学

Abstract The world is undergoing a profound demographic change with a rapid increase in the prevalence of aged individuals. The finitude of life, the burden of senescence and the search for strategies

DataCite Commons2021-03-24 更新90

Table_3_Multi-omics analysis reveals neuroinflammation, activated glial signaling, and dysregulated synaptic signaling and metabolism in the hippocampus of aged mice.XLSX

衰老生物学

海马体研究

Aging is an intricate biological event that occurs in both vertebrates and invertebrates. During the aging process, the brain, a vulnerable organ, undergoes structural and functional alterations, resu

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Transcriptional and epigenetic landscape of the mouse intestine during aging identifies key molecular drivers of aging -associated dysfunctions and diseases. [Total RNA-seq - Lgr5]. Transcriptional and epigenetic landscape of the mouse intestine during aging identifies key molecular drivers of aging -associated dysfunctions and diseases. [Total RNA-seq - Lgr5]

衰老生物学

肠道干细胞

Aging is a complex multifactorial process leading to the loss of tissue/organ functionality and to an increase in disease risk. Aging-related intestinal dysfunctions include loss of barrier integrity,

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衰老生物学

Wnt信号通路

Purpose: Characterize functional alterations in stem cells and paneth cells obtained from young and aged mice, focusing on age-based impairment of intestinal regeneration due to a decline in canonical

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Dietary thiols accelerate aging of C. elegans

衰老生物学

抗衰老药物

We report here on the effects of prolonged supplementation and chronic restriction ofthe major cellular thiol antioxidants, NAC and GSH, on C. elegans physiology and lifespan. Nematodes proved to be a

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Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging

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