Association of symptoms and a low HRQOL with the risk of reaching the combined poor health outcome within the subsequent 6 months based on separate time-dependent Cox proportional hazard models.

The HR with its 95% confidence interval (CI) represents the increased risk of reaching the combined poor health outcome (dialysis, transplantation, and death) within the subsequent 6 months in patients with the symptom compared to patients without the symptom present, the increased risk with each additional symptom, and the increased risk with every 3-point lower physical and mental summary score. A decrease of 3 score points is considered to be clinically relevant. [43] §Adjusted for age, sex, diabetes mellitus, cardiovascular disease, and time dependent eGFR. *p<0.05; **p<0.005.