Scanning ultrasound-mediated improvements in APP23 mice in vivo imaging

This project applies multi-modal Magnetic Resonance Imaging to APP23 mice, a mouse model of AD. Modalities include structural imaging, diffusion imaging, dynamic contrast-enhanced imaging and stimulus-evoked and resting-state functional MRI. APP23 mice were treated with scanning ultrasound at 1 MHz center frequency (HighF), 286 kHz center frequency (LowF) or sham treatment where the ultrasound device was not turned on (Sham). Mice were imaged on a 9.4 T (Bruker Biospin) MRI scanner between 8 and 12 days after the final (8th) HighF, LowF or sham treatment.