Modular Total Syntheses of the Marine-Derived Resorcylic Acid Lactones Cochliomycins A and B Using a Late-Stage Nozaki–Hiyama–Kishi Macrocyclization Reaction
收藏NIAID Data Ecosystem2026-03-06 收录
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资源简介：
The natural products cochliomycin A (1) and cochliomycin B (2), two resorcylic acid lactones obtained from marine sources, have been prepared in a concise and stereocontrolled manner from the readily accessible building blocks 4–6. Olefin cross-metathesis, trans-esterification and Nozaki–Hiyama–Kishi (NHK) macrocyclization reactions were employed in the key steps. Hydrolysis of the immediate precursor to cochliomycin B affords the resorcylic acid lactone zeaenol (24).
创建时间：
2016-02-16
