RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of folic acid may be an effective way to prevent colorectal cancer in
Interventions: Participants will receive six x one hour telephone health coaching sessions over a six week period delivered by study-trained health professionals (‘health coaches’). The health coachin
Interventions: Aspirin (100 mg/day) enteric-coated tablet Placebo tablet / day Primary outcome(s): Only the occurrence of a colorectal tumor (adenoma or cancer) is selected as the primary endpoint. S
This study investigates the potential of EZH2 inhibition as a preventive strategy for colorectal cancer in Lynch Syndrome (LS) by modulating the immune system. Using a mouse model of LS and colonic or
