MixMAP in GLGC identifies IBC array loci that lack single SNP evidence for LDL-C association.

For the 31827 SNPs in 2960 genes interrogated in Global Lipids Genetic Consortium (GLGC) summary data [1], novel loci are detected by MixMAP alone. The median p-values for these genes tend to be lower than expected by chance. †No association with plasma lipids but mouse models support role in atherosclerosis; ‡No association with plasma lipids but cause of inborn error of choline metabolism; **No association with plasma lipids but implicated in Cohen syndrome in which truncal obesity is a feature; ?PPARG is a prominent gene for insulin resistance, type-2 diabetes mellitus, lipodystrophy and obesity; some data link PPARG to lipoprotein abnormalities; indicates corresponding gene detected and – indicates corresponding gene not detected; genome wide significant threshold (); Bonferroni correction based on the number of genes (); Based on published literature (see corresponding citations): A: human data; B: mouse/animal data; and C: cell biology.