Dexmedetomidine inhibited autophagy and mitophagy through suppressing MCU after OGD/R injury .The results of Western blot showed dexmedetomidine downregulated the activation of autophagy and mitophagy
aCompared with PINK1-/-; LacZ. bCompared with Parkin-/-; mRFP. cCompared with LacZ at 28-day-old. dCompared with PINK1-/-; LacZ at 28-day-old. N.D., not determined.
BackgroundPulmonary arterial hypertension (PAH) is a progressive disorder characterized by pulmonary vascular remodeling and mitochondrial dysfunction. Recent studies have implicated impaired mitophag
Gene expression changes were compared in proliferating and senescent human IMR90 cells, with either empty vector, Parkin, or Parkin+CCCP. Method: RNA was extracted, in triplicate, then sequenced with