Homologous recombination deficiency (HRD) contributes to genomic instability and leads to sensitivity to poly ADP-ribose polymerase inhibitors (PARPi). HRD also activates the cyclic GMPâAMP synthase
Treatment phase: The purpose of this study is to evaluate the safety and the immune response elicited by a new anti-cancer therapy in patients with breast cancer in remission but who are at high risk
Pre-Clinical Data for Med paper: Plinabulin Following Radiation Enhances Dendritic Cell Maturation and Checkpoint Inhibitor Retreatment of Relapsed/Refractory Cancers Steven H. Lin1*; Vivek Subbiah2
