<b>Supporting data for "Effects of Bone Marrow-Derived Extracellular Vesicles </b><b>on Fracture Healing"</b>

Fracture healing is an orchestrated process involving intricate interactions between periosteal osteoprogenitor cells and bone marrow (BM) immune cells. However, the specific mechanisms through which cells in these distinct niches communicate remain unclear. In our study, we show that long bone fracture leads to the production of a considerable number of pro-regenerative extracellular vesicles (EVs) derived primarily from immune cells in BM. This dataset, compiled from multiple experiments, unveils a previously unknown mechanism for EVs-based direct communication between BM immune cells and periosteal bone-forming cells, which is crucial for fracture healing.