PRMT5/MEP50 with compound 29 bound
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PRMT5/MEP50 with compound 29 bound Descriptor: (2P)-2-{4-[4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin-6-yl]-1-methyl-1H-pyrazol-5-yl}naphthalene-1-carbonitrile, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, ... Authors: Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Smith, C.R, Kulyk, S, Marx, M.A. Deposit date: 2021-10-01 Release date: 2022-01-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers. J.Med.Chem., 65, 2022
创建时间：
2021-10-01
