differential gene expression profiling in alveolar echinococcosis patients

Alveolar echinococcosis (AE) is a worldwide zoonosis caused by Echinococcus multilocularis, a severe chronic parasitic disease that exhibits a tumor-like growth, with the potential for invasion and distant metastasis. However, the molecular mechanism underlying is unclear. In this study, transcriptome analyses were conducted to detect the differential expression genes in the sample of AE patients with invasion and distant metastasis, the results were further verified by immunohistochemistry. A total of 1796 differentially expressed genes were identified with 1742 upregulated and 54 downregulated. Further function analysis showed that significant genes were participating in the angiogenesis process, Immunohistochemical analysis confirmed the reliability of transcriptomic data.