RPE1-E150-Benchmarking
收藏Zenodo2025-05-14 更新2026-05-26 收录
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https://zenodo.org/doi/10.5281/zenodo.15215414
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资源简介：
Processed dataset of all essential gene CRISPRi perturbations within RPE-1 cells (benchmarking overloading) from:
Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states
Southard KM, Ardy RC, Tang A, O'Sullivan DD, Metzner E, Guruvayurappan K, Norman TM. Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states. bioRxiv [Preprint]. 2024 Aug 3:2024.07.31.606073. doi: 10.1101/2024.07.31.606073. PMID: 39131349; PMCID: PMC11312553.
in press at Nature Genetics
Raw fastq files available at SRA: PRJNA1108254
This record contains aggregated, quality control filtered, and processed outputs downstream of cellranger including.
1) guide umis per cell: rpe1_e150_maxol_exp_norm_crispri_aggr_total_guide_umis.h5
2) final qc filtered population with multiplets: rpe1_e150_maxol_crispri_scanpy_from_cellranger_aggr_singlets_and_multiplets_5umi_cellranger_guide_calls.h5ad
3) regression model benchmarking inputs: RPE1_E150_all_genes.h5ad, rpe1_e150_maxol_crispri_full_design_matrix_guide_identity.csv
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Zenodo创建时间：
2025-05-14
